GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs60843830 | 1 | rs114976176 | chr2:264621 | SH3YL1 | chr2:218138-264810:- | -0.38 | -5.65 | 1.64E-7 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs1875620 | 1 | rs11525966 | chr9:91561936 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs2243480 | 1 | rs11538349 | chr7:65421871 | CCT6P1 | chr7:65216092-65228661:+ | 0.62 | 5.07 | 1.95E-6 | Diabetic kidney disease |
| THYM | cis | rs2463822 | 1 | rs115395195 | chr11:62100353 | ASRGL1 | chr11:62104774-62160885:+ | -0.63 | -6.18 | 1.62E-8 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs78153629 | 1 | rs11541642 | chr15:40683702 | C15orf23 | chr15:40674922-40686488:+ | 0.41 | 4.29 | 4.24E-5 | Heschl's gyrus morphology |
| THYM | cis | rs7223966 | 1 | rs11542436 | chr17:61778689 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.33 | 3.66E-5 | Body mass index |
| THYM | cis | rs60843830 | 1 | rs11553746 | chr2:272203 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs11799420 | 1 | rs11577745 | chr1:171720909 | VAMP4 | chr1:171669298-171711214:- | 0.32 | 4.18 | 6.49E-5 | Hippocampal atrophy |
| THYM | cis | rs11799420 | 1 | rs11578699 | chr1:171719769 | VAMP4 | chr1:171669298-171711214:- | 0.33 | 4.16 | 7.1E-5 | Hippocampal atrophy |
| THYM | cis | rs2275426 | 1 | rs11579634 | chr1:46466391 | CCDC163P | chr1:45960581-45965646:- | 0.5 | 6.08 | 2.51E-8 | Body mass index |
| THYM | cis | rs11799420 | 1 | rs11580522 | chr1:171720978 | VAMP4 | chr1:171669298-171711214:- | -0.34 | -4.38 | 3.06E-5 | Hippocampal atrophy |
| THYM | cis | rs1005224 | 1 | rs1158282 | chr14:76172916 | TTLL5 | chr14:76127621-76421421:+ | 0.36 | 4.96 | 3.04E-6 | Large artery stroke |
| THYM | cis | rs2275426 | 1 | rs11589562 | chr1:46466721 | CCDC163P | chr1:45960581-45965646:- | 0.49 | 5.84 | 7.3E-8 | Body mass index |
| THYM | cis | rs11799420 | 1 | rs11590714 | chr1:171716779 | VAMP4 | chr1:171669298-171711214:- | 0.35 | 4.43 | 2.48E-5 | Hippocampal atrophy |
| THYM | cis | rs2239557 | 1 | rs11628710 | chr14:74649280 | LIN52 | chr14:74551656-74667117:+ | 0.39 | 7.16 | 1.73E-10 | Common traits (Other) |